Protein Details: Voltage-gated Potassium channel-interacting protein 2

Protein ID

ICDB_Pro_1338

Protein Name

Voltage-gated Potassium channel-interacting protein 2

Gene Name

Kcnip2; Kchip2

Organism

Mustela putorius furo (European domestic ferret) (Mustela furo)

Length

270 amino acids

AlphaFoldDB

AF-Q8WN03-F1-model_v4.pdb

Function

Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Modulates channel density; inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro; modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface. Essential for the expression of I(To) currents in the heart. Required for normal protein levels of KCND2 in the heart ventricle (By similarity)

Sequence

MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQALPSVSETLAVPASLRPHRPRPLDPDSVEDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPSGIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTIDDRLNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNKDGVVTIEEFIESCQKDENIMRSMQLFDNVI

PDB Structures

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

153;155;157;159;164;189;191;193;195;200;237;239;241;248

Disease

Location

Expressed in heart ventricle with isoform 1 as most prominent form.

DOI ID

10.1113/jphysiol.2001.015156

RefSeq

XP_004749481.1 [Q8WN03-1]; XP_004749484.1; XP_004749487.1 [Q8WN03-3]